Endocrine Abstracts

Background of study: Experimental research supports the hypothesis that fetal exposure to androgen excess may programme in utero the development of PCOS in adult life. Potential mechanisms for prenatal androgenization could be a reduced binding capacity of androgens by SHBG or reduced aromatization of androgens by aromatase. The aim of this study was to examine whether the SHBG(TAAAA)n polymorphism, known to be associated with SHBG levels and the CYP19(TTTA)n<...